As little is known of the history of the Kaaba, there are various opinions regarding its formation and significance.

The early Arabian population consisted primarily of warring nomadic tribes. When they did converge peacefully, it was usually under the protection of religious practices.[10] Writing in the Encyclopedia of Islam, Wensinck identifies Mecca with a place called Macoraba mentioned by Ptolemy. His text is believed to date from the second century AD, before the rise of Islam,[11] and described it as a foundation in southern Arabia, built around a sanctuary. The area probably did not start becoming an area of religious pilgrimage until around the year AD 500. It was around then that the Quraysh tribe (into which Muhammad was later born) took control of it, and made an agreement with the local Kinana Bedouins for control.[12] The sanctuary itself, located in a barren valley surrounded by mountains, was probably built at the location of the water source today known as the Zamzam Well, an area of considerable religious significance.

Imoti[13] contends that there were multiple such "Kaaba" sanctuaries in Arabia at one time, but this is the only one built of stone. The others also allegedly had counterparts to the Black Stone. There was a "red stone", the deity of the south Arabian city of Ghaiman, and the "white stone" in the Kaaba of al-Abalat (near the city of Tabala, south of Mecca). Grunebaum in Classical Islam points out that the experience of divinity of that time period was often associated with stone fetishes, mountains, special rock formations, or "trees of strange growth."[14]